Computational Biologist Position

Day Zero Diagnostics is a bacterial genomics start-up in Boston that is seeking to recruit a highly motivated computational biologist to join our team. At Day Zero Diagnostics we are modernizing the way infectious diseases are diagnosed and treated by developing a rapid diagnostic that sequences the genomes of pathogenic bacteria, and then uses machine learning methods to identify the cause of the clinical infection.

As a computational biologist, you will be responsible for managing NGS data pipelines and developing microbial genomic data analysis tools. These tools will be used both to aid internal R&D projects, and to provide lab-based services for customer-facing projects. Candidates will gain experience in a multidisciplinary and fast-paced start-up environment, and will have ample opportunities to acquire new skills, work closely with an accomplished team, and communicate results through patents, conference presentations, and peer-reviewed publications while working in a supportive and energetic environment. We value intellectual curiosity and a strong work ethic, and look for candidates who are both excited to contribute their expertise and eager to broaden their skillset to new areas.


Under the direction of the CTO, the applicant independently carries out data analysis tasks, including:

  • Develop and execute analytical tools and reports on hospital outbreaks of bacterial infections
  • Develop and maintain pipelines for NGS data, including Illumina and MinION sequencing data
  • Execute genomic-based lab services for clinical samples
  • Provide genomic expertise on microbial mechanisms of resistance and virulence
  • Perform a variety of bioinformatic tasks
  • Maintain organized, tested code and corresponding documentation
  • Present data within and outside of the company at meetings and symposia
  • Write, edit, and submit manuscripts/abstracts/grants detailing the results of the project
  • Work closely within the group and with outside collaborators
  • Maintain close communications with the team regarding progress


  • PhD with relevant experience in bioinformatics with a strong preference for microbial genomics expertise
  • Fluency in Python, and Linux; familiarity with SQL and git helpful
  • Familiarity with NGS data; familiarity with bioinformatics tools (alignment, variant calling, assembly, annotation); familiarity with ONT MinION data helpful
  • Highly motivated and independent, with the ability to work in a dynamic team environment
  • Strong oral and written communications skills
  • Excellent organizational skills and attention to detail
  • Flexibility to occasionally work evenings or weekends

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